| Project Information |
| Project Title: |
Identification of the molecular pathways controlling the development of functional CD8+ memory T cells |
| Period: |
from: 2011-10-01
to: 2016-09-30
|
| Principal Investigator(s): |
Labrecque, Nathalie
|
| Co-Investigators: |
|
| Supervisors: |
|
| Previous Investigators/Supervisors: |
|
| Institution: |
CIUSSS Est-de-l'Ile-de- Montréal-Maisonneuve Rosemont
|
| Department: |
Médecine et spécialités médicales |
| Agency: |
Canadian Institutes of Health Research |
| Program: |
Operating Grant |
| Keywords: |
BLOOD, CHRONIC INFECTION, IMMUNOLOGICAL MEMORY, IMMUNOLOGIE/TRANSPLANTATION, IMMUNOLOGY-TRANSPLANTATION, INFECTIEUSES ET PARASITAIRES, INFECTIOUS AND PARASITIC, KNOCK-OUT MICE, NOTCH SIGNALING, SANG, T CELLS, VACCINATION |
| Abstract: |
The immune system of an individual is devoted to figth infectious agents. This is achieved by white blood cells that patrol the organism to eliminate pathogens. T cells, a type of white blood cells, are the central player allowing to mount an efficient immune response. These T cells recognize specifically the foreign materials via a cell surface receptor, the T cell receptor(TCR). This recognition allows for the expansion and differentiation of T cells that are specific to the infectious agent. The differentiation of T cells is crucial to allow them to acquire the ability to eliminate the infectious agent. After pathogen clearance, most of the differentiated T cells will die to reset the system. A few of these T cells will survive as long-lived memory T cells. These memory T cells remember their previous encounter with the infectious agent and will therefore respond much more efficiently to a second infection by the same pathogen. The generation of these memory T cells form the basis of vaccination. Therefore, it is critical, to ameliorate vaccination, to better understand how these memory T cells are generated. The overall goal of this proposal is to define the signals that are required for the generation of memory T cells. To do so, we will immunize different mouse mutant models and we will identify the genes controlling memory T cell formation.
|
| Funding Information |
| Fiscal
Year |
Amount |
| 2011-12 |
$71,954
|
| 2012-13 |
$152,241
|
| 2013-14 |
$151,249
|
| 2014-15 |
$141,187
|
| 2015-16 |
$140,449
|
| 2016-17 |
$70,224
|
| Total: |
$727,304 |
|
