| Project Information |
| Project Title: |
PRIZE - Early Career Award in Cancer: Elucidating the role extracellular vesicles play in leukaemogenesis |
| Period: |
from: 2021-03-01
to: 2022-02-28
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| Principal Investigator(s): |
Abraham, Sheela Ann
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| Co-Investigators: |
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| Supervisors: |
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| Previous Investigators/Supervisors: |
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| Institution: |
Queen's University (Kingston, Ontario)
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| Department: |
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| Agency: |
Canadian Institutes of Health Research |
| Program: |
PRIZE - Project Grant - PA: Prize: Early Career Investigator in Cancer |
| Keywords: |
CHRONIC MYELOID LEUKAEMIA, CLONAL HAEMATOPOIESIS, EXTRACELLULAR VESICLES, HAEMATOPOIETIC STEM CELLS, LEUKAEMIA |
| Abstract: |
Chronic myeloid leukaemia (CML) is a blood cancer, which is fatal if left untreated. Specialised tumour cells called cancer stem cells (CSCs) start and maintain leukaemia. Our group will investigate the processes behind how CML slowly develops, and understand how CSCs communicate with other cells using extracellular vesicles (EVs). EVs are lipid nanoparticles that contain bioactive cargo, that transmit/receive signals or important cellular messages. We will investigate if EVs are important in CML, and if EVs help or hinder in the development of leukaemia. Importantly, we will also investigate if EVs can be used as predictors of CML, thus giving tools for doctors to detect leukaemia as early as possible, so people can live longer and healthier lives.
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| Funding Information |
| Fiscal
Year |
Amount |
| 2020-21 |
$25,000
|
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