Detailed information
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The information is provided in the language in which it was submitted by the researcher.
- Project title:
- Skeletal muscle structural and functional adaptations to training- versus immobilization-induced sarcomerogenesis in rats
- Principal investigator(s):
- Hinks, Avery
- Co-investigator(s):
- N/A
- Supervisors:
- N/A
- Institution paid:
- University of Guelph
- Research institution:
- University of Guelph
- Department:
- Human Health and Nutritional Sciences
- Program:
- Master's Award: Canada Graduate Scholarships
- Competition (year/month):
- 202012
- Assigned peer review committee:
- Special Cases - Awards Programs
- Primary institute:
- N/A
- Primary theme:
- N/A
- Term (yrs/mths):
- 1 yr 0 mth
- CIHR contribution:
- Contributors:
- Amount:
- $17,500
- Equipment:
- $0
- External funding partner(s):
- Partner Name:
- N/A
- Amount:
- N/A
- Equipment:
- N/A
- External applicant partner(s):
- Partner Name:
- N/A
- Amount:
- N/A
- Equipment:
- N/A
- External in-kind partner(s):
- Partner Name:
- N/A
- Amount:
- N/A
- Equipment:
- N/A
- Keywords:
- Collagen; Crosslinking; Eccentric Training; Immobilization; Muscle Architecture; Muscle Stretch; Rat Soleus; Sarcomerogenesis; Work Loops
- Abstract/Summary:
- Immobilization of a muscle at a long length and exercise training biased to eccentric contractions both induce hypertrophy by addition of sarcomeres in series. However, less is know about how these experimental interventions influence intramuscular connective tissue, which contributes to force transmission and mechanical efficiency during locomotion. Existing research suggests eccentric training increases collagen content in intramuscular connective tissue while immobilization at a long muscle length results in no change, and there has been little investigation into collagen quality (i.e. collagen fibril crosslinking parameters). Using Sprague-Dawley rats, the present study will investigate adaptations in soleus muscle architecture and intramuscular connective tissue - with attention to both collagen content and crosslinking - following 4 weeks of immobilization of the ankle in a fully dorsiflexed position or eccentric-biased training induced by weighted downhill running. Additionally, work loop performance will be tested on the soleus in vitro to investigate the impact of differential collagen adaptations with increased serial sarcomere number on mechanical efficiency during locomotion.
- Version:
- 20250311.1