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Titre du projet :

The development of memory and mentalizing networks in autism

Chercheur principal :

Chai, Xiaoqian

Co-chercheurs :

Bzdok, Danilo; Elsabbagh, Mayada

Directeur(s) de recherche :

S/O

Établisssement payé :

Université McGill

Établissement de recherche :

Université McGill

Département :

S/O

Programme :

Subv. Pr.- AP : Développement et santé des enfants et des adol. - CDC

Concours (année/mois) :

202209

CEP désigné :

Sciences du comportement - B-2

Institut principal :

Neurosciences, santé mentale et toxicomanies

Thème principal :

Recherche biomédicale

Durée (année/mois) :

1 an 0 mois

Contribution des IRSC :

Donateurs :

Montant :

100 000$

Équipement :

0$

Contribution du partenaire externe :

Nom du partenaire :

S/O

Montant :

S/O

Équipement :

S/O

Partenaire du candidat à l'externe :

Nom du partenaire :

S/O

Montant :

S/O

Équipement :

S/O

Partenaire externe (en nature) :

Nom du partenaire :

S/O

Montant :

S/O

Équipement :

S/O

Mots clés :

Autism; Brain Networks; Development; Episodic Memory; Social Cognition; Theory Of Mind

Résumé :

Individuals with autism are impaired in social communication, and also show deficits in their memory of past events and experiences (episodic memory) and in social cognition (understanding thoughts about self and others). Previous research has shown that social cognition and episodic memory processes involve distributed regions in the brain that overlap with the default mode network, a large-scale brain network involved in internal mental processes such as autobiographical memory, social cognition and self-related thoughts. Recent evidence suggests the default mode network consists of two distinct subnetworks subserving memory and social cognition. In the proposed research, we will test whether these subnetworks are less separated and specialized in autism, and whether less specialized subnetworks contributes to social deficits in autism. We will conduct functional Magnetic Resonance Imaging (fMRI) sessions with passive movie-watching and memory tasks in a group of children with high-functioning autism and neurotypical controls. Using network analysis and a memory task that involves thinking about self and other, we will examine how these two subnetworks of the default network develop in ASD and controls. We will test the interaction of these two networks with other relevant functional networks in the brain related to attention and control. Structural MRI and other phenotypic measures such as IQ, language background and sleep patterns will also be analyzed for consideration of subtypes within the sample. The proposed research takes a network-level view of social communication dysfunctions in ASD to test a novel hypothesis linking social deficits with atypicality in the development of the social cognitive and memory network in the brain.

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Version :

20250311.1